2011

Willemse, J., Borst, J.W., de Waal, E., Bisseling, T., van Wezel, G.P. , Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces, Genes & Development, vol. 25, no. 1, pp. 89-99.

Barends, S., Barend, K., van Wezel, G. , The tmRNA-tagging mechanism and the control of gene expression: a review, Wiley Interdiscip Rev RNA , vol. 2, pp. 233-246.

van Wezel, G.P., McDowall, K.J. , The regulation of the secondary metabolism of Streptomyces: new links and experimental advances, Natural Product Reports, vol. 28, no. 7, pp. 1311-1333.

2010

Nothaft, H., Rigali, S., Boomsma, B., Swiatek, M., McDowall, K.J., van Wezel, G.P., Titgemeyer, F. , The permease gene nagE2 is the key to N-acetylglucosamine sensing and utilization in Streptomyces coelicolor and is subject to multi-level control, Molecular Microbiology, vol. 75, no. 5, pp. 1133-1144.

Barends, S., Zehl, M., Bialek, S., de Waal, E., Traag, B.A., Willemse, J., Jensen, O.N., Vijgenboom, E., van Wezel, G.P. , Transfer-messenger RNA controls the translation of cell-cycle and stress proteins in Streptomyces, Embo Reports, vol. 11, no. 2, pp. 119-125.

Willemse, J., Borst, J.W., de Waal, E., Bisseling, T., van Wezel, G.P. , Positive control fo cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces (accepted for publication), Genes Dev.

2009

Tian, T., Mutikainen, I, van Wezel, G.P., Aliaga-Alcalde, N., Reedijk, J. , Chemical, structural and biological studies of cis-[Pt(3-Acpy)(2)Cl-2], Journal of Inorganic Biochemistry, vol. 103, no. 9, pp. 1221-1227.

Roy, S., Westmaas, J.A., Hagen, K.D., van Wezel, G.P., Reedijk, J. , Platinum(II) compounds with chelating ligands based on pyridine and pyrimidine: DNA and protein binding studies, Journal of Inorganic Biochemistry, vol. 103, no. 9, pp. 1288-1297.

Birko, Z., Swiatek, M., Szajli, E., Medzihradszky, K.F., Vijgenboom, E., Penyige, A., Keseru, J., van Wezel, G.P., Biro, S. , Lack of A-factor Production Induces the Expression of Nutrient Scavenging and Stress-related Proteins in Streptomyces griseus, Molecular & Cellular Proteomics, vol. 8, no. 10, pp. 2396-2403.

Willemse, J., van Wezel, G.P. , Imaging of Streptomyces coelicolor A3(2) with Reduced Autofluorescence Reveals a Novel Stage of FtsZ Localization, Plos One, vol. 4, no. 1, pp. -.

van Wezel, G.P., McKenzie, N.L., Nodwell, J.R. , Applying the Genetics of Secondary Metabolism in Model Actinomycetes to the Discovery of New Antibiotics, Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides, vol. 458, pp. 117-+.

Roy, S., Maheswari, P.U., Lutz, M., Spek, A.L., den Dulk, H., Barends, S., van Wezel, G.P., Hartl, F., Reedijk, J. , DNA cleavage and antitumour activity of platinum(II) and copper(II) compounds derived from 4-methyl-2-N-(2-pyridylmethyl)aminophenol: spectroscopic, electrochemical and biological investigation, Dalton Transactions, no. 48, pp. 10846-10860.

2008

Roy, S., Hagen, K.D., Maheswari, P.U., Lutz, M., Spek, A.L., Reedijk, J., van Wezel, G.P. , Phenanthroline derivatives with improved selectivity as DNA-targeting anticancer or antimicrobial drugs, Chemmedchem, vol. 3, no. 9, pp. 1427-1434.

Maheswari, P.U., van der Ster, M., Smulders, S., Barends, S., van Wezel, G.P., Massera, C., Roy, S., den Dulk, H., Gamez, P., Reedijk, J. , Structure, cytotoxicity, and DNA-cleavage properties of the complex [Cu-II(pbt)Br-2], Inorganic Chemistry, vol. 47, no. 9, pp. 3719-3727.

Traag, B.A., van Wezel, G.P. , The SsgA-like proteins in actinomycetes: small proteins up to a big task, Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology, vol. 94, no. 1, pp. 85-97.

Rigali, S., Titgemeyer, F., Barends, S., Mulder, S., Thomae, A.W., Hopwood, D.A., van Wezel, G.P. , Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces, Embo Reports, vol. 9, no. 7, pp. 670-675.

Colson, S., van Wezel, G.P., Craig, M., Noens, E.E.E., Nothaft, H., Mommaas, A.M., Titgemeyer, F., Joris, B., Rigali, S. , The chitoblose-binding protein, DasA, acts as a link between chitin utilization and morphogenesis in Streptomyces coelicolor, Microbiology-Sgm, vol. 154, pp. 373-382.

2007

Olsthoorn-Tieleman, L.N., Palstra, R.J.T.S., van Wezel, G.P., Bibb, M.J., Pleij, C.W.A. , Elongation factor TO (EF-Tu3) from the kirromycin producer Streptomyces ramocissimus is resistant to three classes of EF-Tu-specific inhibitors, Journal of Bacteriology, vol. 189, no. 9, pp. 3581-3590.

Hiard, S., Maree, R., Colson, S., Hoskisson, P.A., Titgemeyer, F., van Wezel, G.P., Joris, B., Wehenkel, L., Rigali, S. , PREDetector: A new tool to identify regulatory elements in bacterial genomes, Biochemical and Biophysical Research Communications, vol. 357, no. 4, pp. 861-864.

Noens, E.E., Mersinias, V., Willemse, J., Traag, B.A., Laing, E., Chater, K.F., Smith, C.P., Koerten, H.K., van Wezel, G.P. , Loss of the controlled localization of growth stage-specific cell-wall synthesis pleiotropically affects developmental gene expression in an ssgA mutant of Streptomyces coelicolor, Molecular Microbiology, vol. 64, no. 5, pp. 1244-1259.

Birko, Z., Bialek, S., Buzas, K., Szajli, E., Traag, B.A., Medzihradszky, K.F., Rigali, S., Vijgenboom, E., Penyige, A., Kele, Z., van Wezel, G.P., Biro, S. , The secreted signaling protein factor C triggers the A-factor response regulon in streptomyces griseus - Overlapping signaling routes, Molecular & Cellular Proteomics, vol. 6, no. 7, pp. 1248-1256.

Traag, B.A., Seghezzi, N., Vijgenboom, E., van Wezel, G.P. , Characterization of the sporulation control protein SsgA by use of an efficient method to create and screen random mutant libraries in streptomycetes, Applied and Environmental Microbiology, vol. 73, no. 7, pp. 2085-2092.

van Wezel, G.P., Konig, M., Mahr, K., Nothaft, H., Thomae, A.W., Bibb, M., Titgemeyer, F. , A new piece of an old jigsaw: Glucose kinase is activated posttranslationally in a glucose transport-dependent manner in Streptomyces coelicolor A3(2), Journal of Molecular Microbiology and Biotechnology, vol. 12, no. 1-2, pp. 67-74.

Colson, S., Stephan, J., Hertrich, T., Saito, A., van Wezel, G.P., Titgemeyer, F., Rigali, S. , Conserved cis-acting elements upstream of genes composing the chitinolytic system of streptomycetes are DasR-responsive elements, Journal of Molecular Microbiology and Biotechnology, vol. 12, no. 1-2, pp. 60-66.

Maheswari, P.U., Lappalainen, K., Sfregola, M., Barends, S., Gamez, P., Turpeinen, U., Mutikainen, I, van Wezel, G.P., Reedijk, J. , Structure and DNA cleavage properties of two copper(II) complexes of the pyridine-pyrazole-containing ligands mbpzbpy and Hmpzbpya, Dalton Transactions, no. 33, pp. 3676-3683.

Gilles van Wezel teaches or supervises the following courses:

• Biochemie 3 (LB2441-fg)
• Global Regulatory Networks in Bacteria (GRNB)

Gilles currently supervises the following students:

• Dino van Dissel